SYNTHETIC PEPTIDES TESTING

Brand	Owner	Address	Description
PROTEOMICS TOOLBOX	Bac IP B.V.	Huizerstraatweg 28 1411 GP Naarden Netherlands	Synthetic peptides for the testing of body fluids; nutritive substances for micro-organisms for medical use;Biomedical compounds, namely, peptide substrates used in analyzing and detecting certain toxins for laboratory, research, clinical or medical laboratory use; protein arrays and nucleotide arrays for scientific and medical research; biochemicals, namely, monoclonal antibodies for in vitro scientific or research use;PROTEOMICS;
	Where the owner name is not linked, that owner no longer owns the brand

Technical Examples

The present invention provides synthetic chimeric fimbrin peptides which induce an immunogenic response in animals to non-typable Haemophilus influenzae and that do not require tedious purification techniques. The synthetic chimeric fimbrin peptides reduce the severity of otitis media caused by Haemophilus influenzae. The synthetic chimeric fimbrin peptides are synthesized using commercially available peptide synthesizers. The synthetic chimeric fimbrin peptides comprises three peptide units. The first peptide unit is a subunit of the fimbrin protein. Preferably, the fimbrin subunit is comprised of the amino acids of Sequence ID No. 1 or Sequence ID No. 2. The second peptide unit is a t cell epitope, and preferably has the amino acid sequence of SEQ ID NO. 3. The third peptide unit is a linker peptide unit which joins the first and second peptide unit. The linking sequence preferably has from about 2 to about 15 amino acids, more preferably from about 2 to about 10 amino acids, most preferably from about 5 to about 6 amino acids. The synthetic chimeric fimbrin peptides are useful immunognes against NTHi and also useful as laboratory tool for detecting antibodies in sera. The invention also relates to an immunogenic composition containing the synthetic chimeric fimbrin peptides and a pharmacologically acceptable carrier.