GROWTH FACTORS BIOCHEMICAL INTERMEDIATES

Brand	Owner (click to sort)	Address	Description
IMCERA	MALLINCKRODT SPECIALTY CHEMICALS COMPANY	16305 SWINGLEY RIDGE DRIVE CHESTERFIELD MO 63017	GROWTH FACTORS AND BIOCHEMICAL INTERMEDIATES FOR USE IN CELL TISSUE AND ORGAN CULTURE;
IMCERA	IMCERA BIOPRODUCTS, INC.	1331 SOUTH FIRST STREET TERRE HAUTE IN 47802	GROWTH FACTORS AND BIOCHEMICAL INTERMEDIATES FOR USE IN CELL TISSUE AND ORGAN CULTURE;
	Where the owner name is not linked, that owner no longer owns the brand

Technical Examples

An organotypic culture comprises an artificial stroma overlayed with epithelial cells isolated from a human colon or intestine. The stroma comprises a mixture of collagen and human fibroblasts isolated from a human colon or intestine. The culture contains a factor that binds the IGF-1 receptor, a factor that binds the EGF receptor, and a factor that binds the LIF receptor. These factors may be added exogenously to the culture via medium or may be expressed by various recombinantly engineered cell types in the culture. The organotypic culture can result in growth that is in situ-like or emphasizes other physiological or morphological states, depending on the balance of factors in the growth media. The organotypic culture may be used in methods for screening of therapeutic, carcinogenic, or growth enhancement factors, or for treating intestinal injuries by applying to the site of an injury the intact culture or the components thereof.