GENETICALLY ENGINEERED TISSUE ORGANS

Brand	Owner	Address	Description
REGENIC	Tsuji, Noriaki	1540 5th Avenue, Apartment #101 San Francisco CA 94122	GENETICALLY ENGINEERED TISSUE AND ORGANS INTENDED FOR SUBSEQUENT IMPLANTATION;
	Where the owner name is not linked, that owner no longer owns the brand

Technical Examples

The disclosure provides methods and systems for tissue engineering including an apparatus and methods for the growth, maintenance, and use of robust tissue sheets using tissue manipulation devices. The tissue manipulation devices provide a method of anchoring the tissue sheets to the cell culture substrate to promote prolonged maturation and subsequent increased mechanical strength. The tissue manipulation devices also provide a technique to facilitate removal of the sheet from the culture container and subsequent production steps to assemble more complex three dimensional organs from the robust sheet. The tissue manipulation devices also facilitate automated handling of the sheets in the assembly processes. The disclosure provides methods and composition derived from robust human sheets to build tissue engineered blood vessels, heart valves, stents, and endarterectomy patches and the like. The use of these tissue manipulation devices facilitates the assembly of complex tissue engineered organs using the novel sheet-based tissue engineering approach.