Brands and Their Owners
Patent Number: 9387251
Patent Date: 2016-07-12
Patent type: utility
This invention relates to a composition and its use for formulating nucleic acid-based drugs/vaccines with sugar alcohol compositions into complexes for both in-vitro and in-vivo delivery. Particularly, the present invention includes the ingredients and processes necessary for formulating therapeutic and pharmaceutical nucleic acid compositions, such as miRNA, microRNA precursors, shRNAs, siRNAs, ribozymes, antisense RNAs/DNAs, RNA-DNA hybrids and DNA vectors/vaccines, with glycylated sugar alcohols/sugars into delivery complexes, which can then be absorbed by cells in vivo and in vitro via active endocytosis. Also, the present invention discloses that chemical compounds containing sugar alcohol- and/or sugar-like structures can protect nucleic acids, in particular miRNAs, shRNAs, siRNAs and ribozymes, from degradation in vivo as well as in vitro. Therefore, the present invention is also a formula and method for preserving the structural integrity and functional efficacy of these nucleic acid-based drugs and/or vaccines in vivo and in vitro.
Inventors
First Name | Last Name | City | State | Country |
---|---|---|---|---|
Shi-Lung | Lin | - | - | - |
Yi-Wen | Lin | - | - | - |
IPCs
Section | Class | Sub Class | Group | Sub Group |
---|---|---|---|---|
A | 61 | K | 47 | 26 |
A | 61 | K | 31 | 713 |
A | 61 | K | 31 | 7105 |
C | 12 | N | 15 | 11 |
C | 12 | N | 15 | 113 |
Assignee
Organization | First Name | Last Name | City | State | Country |
---|---|---|---|---|---|
- | Shi-Lung | Lin | - | - | - |
- | David TS | Wu | - | - | - |